Rothamsted Research is one if eight institutes sponsored by the biotechnology and biological sciences research council



The following represents a selection of our recent publications relevant to the field of metabolomics.


  • John M. Baker, Nathaniel D. Hawkins, Jane L. Ward, Alison Lovegrove, Johnathan A. Napier, Peter R. Shewry and Michael H. Beale (2006)* A metabolomic study of substantial equivalence of field-grown GM wheat. Plant Biotechnology Journal 4(4), 381-392


  • Sandra J. Hey, Stephen J. Powers, Michael H. Beale, Nathaniel D Hawkins, Jane L. Ward and Nigel G. Halford. (2006) Enhanced seed phytosterol accumulation through expression of a modified HMG-CoA reductase. Plant Biotechnology Journal. 4, 219-229


  • Paul Chilley, Stuart Casson, Petr Tarkowski, Nathan Hawkins, Kevin Wang, Patrick Hussey, Mike Beale, Göran Sandberg and Keith Lindsey. The POLARIS peptide of Arabidopsis regulates auxin transport and root growth via effects on ethylene signalling. (2006). Plant Cell,


  • Jane L. Ward and Michael H. Beale (2005) NMR Spectroscopy in Plant Metabolomics, In Plant Metabolomics, Biotechnology in Agriculture and Forestry series, (eds K. Saito, R. Dixon and L. Willmitzer) Springer, Heidelberg


  • Gopalakrishnan, S., Beale, M.H., Ward, J.L. and Strange, R.N. (2005) Chickpea wilt: identification and toxicity of 8-O-methyl-fusarubin from Fusarium acutatum.  Phytochemistry, 66, 1536-1539


  • Rasha El-Kassas, Zaharaa Karam El-Din, Michael H. Beale, Jane L. Ward and Richard N. Strange. (2005) Bioassay-led identification of Myrothecium verrucaria and verrucarrin A as germination inhibitors of Orobanche crenata. Weed Research, 45, 211-219


  • Borner GHH, Sherrier DJ, Weimar T, Michaelson LV, Hawkins ND, MacAskill A, Napier JA, Beale MH, Lilley KS, Dupree P (2005) Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts Plant Physiology 137 (1): 104-116


  • Naested H, Holm A, Jenkins T, Nielsen HB, Harris CA, Beale MH, Andersen M, Mant A, Scheller H, Camara B, Mattsson O, Mundy J (2004) Arabidopsis VARIEGATED 3 encodes a chloroplast-targeted, zinc-finger protein required for chloroplast and palisade cell development J Cell Science, 117, 4807-4818.


  • Lewis, J., Baker, J. Beale, M.H. and Ward, J. L. (2004) Metabolite Profiling of GM Plants: The Importance of Robust Experimental Design and Execution. In Genomics for Biosafety in Plant Biotechnology (Eds Nap, J.P.H., Atanassov, A and  Stiekema, W.J) IOS Press, Amsterdam  pp47-57


  • Cornah, J.E., Germain, V., Ward, J.L., Beale, M.H., Smith, S.M. (2004) Lipid Utilisation, gluconeogenesis and seedling growth in Arabidopsis mutants lacking the glyoxylate cycle enzyme malate synthase. J. Biol. Chem., 279, 42916-42923


  • Bino, R.J., Hall, R.D., Feihn, O, Beale, M.H. et al (2004) Potential of Metabolomics as a Functional Genomics Tool. Trends in Plant Science. 9, 418-425


  • Ward, J. L., Harris, C., Lewis, J. and Beale, M. H. (2003) Assessment of 1H-NMR spectroscopy and multivariate analysis as a technique for metabolite fingerprinting of Arabidopsis thaliana. Phytochemistry, 62, 949-957


  • Hall, R, Beale, MH, Fiehn, O., Hardy, N., Sumner, L and Bino, R. (2002) Plant metabolomics as the holy grail for functional genomics Plant Cell , 14, 1437-1440


  • Beale, M.H, Dupree, P., Lilley, K., Beynon, J., Trick, M., Clarke, J., Bevan, M., Bancroft, I., Jones, J., May, S., van de Sande, K. and Leyser, O (2002) GARNet, the Genomic Arabidopsis Resource Network, Trends in Plant Sciences,7, 145-147


  • Williams, J.S., Hall, S. A., Hawkesford, M.J., Beale, M. H. and Cooper, R. M. (2002) Elemental Sulfur and Thiol Accumulation in Tomato and Defense against a Fungal Vascular Pathogen, Plant Physiology, 128, 150-159


  • Sessa, R.A, Bennett, M.H., Lewis ,M.J., Mansfield, J. W and Beale M.H (2000) Metabolite profiling of  sesquiterpene lactones from Lactuca species. J. Biol. Chem. 275, 26877-26884


  • McLusky, S. R., Bennett, M.H., Beale, M.H., Lewis, M.J., Gaskin, P. and Mansfield, J. W. (1999) Cell-wall alterations and localised accumulation of feruloyl-3’-methoxytyramine in onion epidermis at sites of attempted penetration by Botrytis alliii are associated with actin polarisation, peroxidase activity and suppression of flavonoid biosynthesis. Plant Journal, 17, 523-534


  • Resende, M.L.V, Flood, J. Ramsden, J.D. , Rowan M.G, Beale. M.H. and Cooper, R.M. (1996) Novel phytoalexins including elemental sulphur in the resistance of cocoa (Threobroma cacao L.) to verticillium wilt (Verticillium dahliae Kleb). Physiol Mol. Plant Pathol. 48, 347-359


·         Cooper, R.M., Resende, M.L.V, Flood, J., Rowan M.G, Beale. M.H. and Potter, U., (1996) Detection and Cellular Location of Elemental Sulphur in Disease-resistant Genotypes of Threobroma cacao., Nature, 379, 159-162


·         Perez-Amador, M.A., Carbonell, J., Navarro, J.L., Moritz, T., Beale, M.H., Lewis, M.J. and Hedden, P. (1996) N4-Hexanoylspermidine, a New polyamine-related Compound that Accumulates during Ovary and Petal Senescence in Pea. Plant Physiol. 110, 1177-1186.


  • Bennett, M., Gallagher, M., Fagg, J., Bestwick, C., Paul, T., Beale, M.H. and Mansfield, J., (1996) The hypersensitive reaction, membrane damage and accumulation of autofluorescent phenolics in lettuce cells challenged by Bremia lactucae. Plant Journal, 9, 851-865